Dual Enzyme-Triggered Controlled Release on Capped Nanometric Silica Mesoporous Supports

被引：56

作者：

Agostini, Alessandro ^{[1
,2
]}

Mondragon, Laura ^{[1
,2
]}

Coll, Carmen ^{[1
,2
]}

Aznar, Elena ^{[1
]}

Marcos, M. Dolores ^{[1
,2
]}

Martinez-Manez, Ramon ^{[1
,2
]}

Sancenon, Felix ^{[1
,2
]}

Soto, Juan ^{[1
,2
]}

Perez-Paya, Enrique ^{[3
]}

Amoros, Pedro ^{[4
]}

机构：

[1] Univ Valencia, Ctr Reconocimiento Mol Desarrollo & Tecnol, Unidad Mixta Univ Politecn Valencia, E-46003 Valencia, Spain

[2] Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain

[3] Ctr Invest Principe Felipe, Lab Peptidos & Prot, Valencia 46012, Spain

[4] Univ Valencia, Inst Ciencia Mat ICMUV, Valencia 46071, Spain

来源：

CHEMISTRYOPEN | 2012年 / 1卷 / 01期

关键词：

controlled release; drug delivery; mesoporous materials; nanoparticles; urease; GUEST MOLECULES; PH; DELIVERY; SYSTEM; DESIGN;

D O I：

10.1002/open.201200003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Please release me: Mesoporous silica nanoparticles capped with bulky organic moieties containing amide and urea linkages were able to release their cargo upon addition of amidase and urease. Amidase induced an immediate, yet not complete, release of the cargo. On the other hand, urease allowed a near total cargo release that was delayed in time (see graph). © 2012 The Authors.

引用

页码：17 / 20

页数：4

共 56 条

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