Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry

被引：41

作者：

Deventer, K ^{[1
]}

Van Eenoo, P ^{[1
]}

Delbeke, FT ^{[1
]}

机构：

[1] Univ Ghent, Dept Clin Chem Microbiol & Immunol, Doping Control Lab, B-9052 Zwijnaarde, Belgium

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2006年 / 20卷 / 05期

关键词：

D O I：

10.1002/rcm.2372

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A selective and sensitive method for the qualitative screening of urine samples for 27 amphetamine and amphetamine-type drugs in the field of doping analysis is described. The method consists of a liquid-liquid extraction with diethyl ether at pH 14 and analysis of the extracts with a LCQ-Deca((R)) mass spectrometer equipped with an atmospheric pressure chemical ionisation interface, operated in positive ionisation mode. The total run time was 15 min. All compounds were analysed in MS2 or MS3. The detection limit for all compounds was lower than 25 ng/mL except for chlorphentermine (detection limit: 250 ng/mL). Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：877 / 882

页数：6

共 26 条

[1]

[Anonymous], LAB GUIDE METHOD VAL

[2] Analysis of underivatized amphetamines and related phenethylamines with high-performance liquid chromatography -: Atmospheric pressure chemical ionization mass spectrometry [J].

Bogusz, MJ ;

Krüger, KD ;

Maier, RD .

JOURNAL OF ANALYTICAL TOXICOLOGY, 2000, 24 (02) :77-84

[3] Detection and quantitation of amphetamine and methamphetamine: Electron impact and chemical ionization with ammonia-comparative investigation on Shimadzu QP 5000 GC-MS system [J].

Dallakian, P ;

Budzikiewicz, H ;

Brzezinka, H .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1996, 20 (04) :255-261

[4] Clinical pharmacokinetics of amfetamine and related substances -: Monitoring in conventional and non-conventional matrices [J].

de la Torre, R ;

Farré, M ;

Navarro, M ;

Pacifici, R ;

Zuccaro, P ;

Pichini, S .

CLINICAL PHARMACOKINETICS, 2004, 43 (03) :157-185

[5]

Edeleanu L., 1887, BERL DTSCH CHEM GEN, V20, P616, DOI DOI 10.1002/CBER.188702001142

[6] Central nervous system stimulants [J].

George, AJ .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 14 (01) :79-88

[7] Quantification of ephedrines in urine by column-switching high-performance liquid chromatography [J].

Gmeiner, G ;

Geisendorfer, T ;

Kainzbauer, J ;

Nikolajevic, M ;

Tausch, H .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2002, 768 (02) :215-221

[8] Stimulants, narcotics and beta-blockers: 25 years of development in analytical techniques for doping control [J].

Hemmersbach, P ;

delaTorre, R .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1996, 687 (01) :221-238

[9] Single-step procedure for gas chromatography-mass spectrometry screening and quantitative determination of amphetamine-type stimulants and related drugs in blood, serum, oral fluid and urine samples [J].

Kankaanpää, A ;

Gunnar, T ;

Ariniemi, K ;

Lillsunde, P ;

Mykkänen, S ;

Seppälä, T .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 810 (01) :57-68

[10] Toxicokinetics of amphetamines: Metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives [J].

Kraemer, T ;

Maurer, HH .

THERAPEUTIC DRUG MONITORING, 2002, 24 (02) :277-289

← 1 2 3 →