Rhabdomyolysis: A review

被引:289
作者
Warren, JD
Blumbergs, PC
Thompson, PD [1 ]
机构
[1] Univ Adelaide, Royal Adelaide Hosp, Dept Neurol, Adelaide, SA, Australia
[2] Inst Med & Vet Sci, Dept Neuropathol, Adelaide, SA, Australia
[3] Univ Adelaide, Royal Adelaide Hosp, Dept Med, Adelaide, SA 5000, Australia
关键词
fatty acid oxidation disorders; hyperthermic syndromes; metabolic myopathy; rhabdomyolysis;
D O I
10.1002/mus.10053
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements may ensue. A diverse spectrum of inherited and acquired disorders affecting muscle membranes, membrane ion channels, and muscle energy supply causes rhabdomyolysis. Common final pathophysiological mechanisms among these causes of rhabdomyolysis include an uncontrolled rise in free intracellular calcium and activation of calcium-dependent proteases, which lead to destruction of myofibrils and lysosomal digestion of muscle fiber contents. Recent advances in molecular genetics and muscle enzyme histochemistry may enable a specific metabolic diagnosis in many patients with idiopathic recurrent rhabdomyolysis. (C) 2002 Wiley Periodicals, Inc.
引用
收藏
页码:332 / 347
页数:16
相关论文
共 173 条
[111]   Malignant-hyperthermia susceptibility is associated with a mutation of the alpha(1)-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle [J].
Monnier, N ;
Procaccio, V ;
Stieglitz, P ;
Lunardi, J .
AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 60 (06) :1316-1325
[112]   Fatty acid oxidation defects in muscle [J].
Morris, AAM ;
Turnbull, DM .
CURRENT OPINION IN NEUROLOGY, 1998, 11 (05) :485-490
[113]   Marinesco Sjogren syndrome with rhabdomyolysis - A new subtype of the disease [J].
Muller-Felber, W ;
Zafiriou, D ;
Scheck, R ;
Patzke, I ;
Toepfer, M ;
Pongratz, DE ;
Walther, U .
NEUROPEDIATRICS, 1998, 29 (02) :97-101
[114]  
Nehoda H, 1998, HEPATO-GASTROENTEROL, V45, P191
[115]   Clinical rhabdomyolysis [J].
Ng, YT ;
Johnston, HM .
JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2000, 36 (04) :397-400
[116]   Muscle pain after exercise [J].
Nielsen, C ;
Mazzone, P .
LANCET, 1999, 353 (9158) :1062-1062
[117]   SKELETAL-MUSCLE FIBER CHARACTERISTICS IN YOUNG-WOMEN [J].
NYGAARD, E .
ACTA PHYSIOLOGICA SCANDINAVICA, 1981, 112 (03) :299-304
[118]   MUSCLE COENZYME-Q DEFICIENCY IN FAMILIAL MITOCHONDRIAL ENCEPHALOMYOPATHY [J].
OGASAHARA, S ;
ENGEL, AG ;
FRENS, D ;
MACK, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2379-2382
[119]   VERY LONG-CHAIN ACYL COENZYME-A DEHYDROGENASE-DEFICIENCY PRESENTING WITH EXERCISE-INDUCED MYOGLOBINURIA [J].
OGILVIE, I ;
POURFARZAM, M ;
JACKSON, S ;
STOCKDALE, C ;
BARTLETT, K ;
TURNBULL, DM .
NEUROLOGY, 1994, 44 (03) :467-473
[120]   MITOCHONDRIAL-DNA DELETIONS IN INHERITED RECURRENT MYOGLOBINURIA [J].
OHNO, K ;
TANAKA, M ;
SAHASHI, K ;
IBI, T ;
SATO, W ;
YAMAMOTO, T ;
TAKAHASHI, A ;
OZAWA, T .
ANNALS OF NEUROLOGY, 1991, 29 (04) :364-369