Rhabdomyolysis: A review

被引:289
作者
Warren, JD
Blumbergs, PC
Thompson, PD [1 ]
机构
[1] Univ Adelaide, Royal Adelaide Hosp, Dept Neurol, Adelaide, SA, Australia
[2] Inst Med & Vet Sci, Dept Neuropathol, Adelaide, SA, Australia
[3] Univ Adelaide, Royal Adelaide Hosp, Dept Med, Adelaide, SA 5000, Australia
关键词
fatty acid oxidation disorders; hyperthermic syndromes; metabolic myopathy; rhabdomyolysis;
D O I
10.1002/mus.10053
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements may ensue. A diverse spectrum of inherited and acquired disorders affecting muscle membranes, membrane ion channels, and muscle energy supply causes rhabdomyolysis. Common final pathophysiological mechanisms among these causes of rhabdomyolysis include an uncontrolled rise in free intracellular calcium and activation of calcium-dependent proteases, which lead to destruction of myofibrils and lysosomal digestion of muscle fiber contents. Recent advances in molecular genetics and muscle enzyme histochemistry may enable a specific metabolic diagnosis in many patients with idiopathic recurrent rhabdomyolysis. (C) 2002 Wiley Periodicals, Inc.
引用
收藏
页码:332 / 347
页数:16
相关论文
共 173 条
[11]   IDIOPATHIC RECURRENT MYOGLOBINURIA AND PERSISTENT WEAKNESS [J].
BERMILS, C ;
TASSIN, S ;
BRUCHER, JM ;
DEBARSY, T .
NEUROLOGY, 1983, 33 (12) :1613-1615
[12]  
BETTER OS, 1990, NEW ENGL J MED, V322, P825
[13]   THE RISK OF RHABDOMYOLYSIS AND ACUTE-RENAL-FAILURE WITH THE PATIENT IN THE EXAGGERATED LITHOTOMY POSITION [J].
BILDSTEN, SA ;
DMOCHOWSKI, RR ;
SPINDEL, MR ;
AUMAN, JR .
JOURNAL OF UROLOGY, 1994, 152 (06) :1970-1972
[14]  
BILLIS AG, 1971, LANCET, V2, P702
[15]   TEXTURE RHABDOMYORHEXIS - A PSEUDO-CRUSH SYNDROME [J].
BLOOM, AI ;
ZAMIR, G ;
MUGGIA, M ;
FRIEDLAENDER, M ;
GIMMON, Z ;
RIVKIND, A .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1995, 38 (02) :252-254
[16]   SEROTONIN SYNDROME [J].
BODNER, RA ;
LYNCH, T ;
LEWIS, L ;
KAHN, D .
NEUROLOGY, 1995, 45 (02) :219-223
[17]   Rhabdomyolysis associated with near-drowning [J].
Bonnor, R ;
Siddiqui, M ;
Ahuja, TS .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1999, 318 (03) :201-202
[18]  
BRESOLIN N, 1987, LANCET, V2, P212
[19]  
BRITT BA, 1996, HDB MUSCLE DIS, P451
[20]  
BRUMBACK RA, 1992, PEDIATR CLIN N AM, V39, P821