Membrane channel formation by antimicrobial protegrins

被引：108

作者：

Sokolov, Y

Mirzabekov, T

Martin, DW

Lehrer, RI

Kagan, BL

机构：

[1] Univ Calif Los Angeles, Inst Neuropsychiat, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Mental Retardat Res Ctr, Los Angeles, CA 90024 USA

[5] W Los Angeles Vet Affairs Med Ctr, Los Angeles, CA 90073 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1420卷 / 1-2期

关键词：

antimicrobial peptide; lipopolysaccharide; membrane channel; protegrin;

D O I：

10.1016/S0005-2736(99)00086-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protegrins are small, arginine- and cysteine-rich, beta-sheet peptides with potent activity against bacteria, fungi, and certain enveloped viruses. We report that protegrins form weakly anion-selective channels in planar phospholipid bilayers, induce potassium leakage from liposomes and form moderately cation-selective channels in planar lipid membranes that contain bacterial lipopolysaccharide. The disruption of microbial membranes may be a central attribute related to the host defense properties of protegrins. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：23 / 29

页数：7

共 22 条

[11] ANTIMICROBIAL DEFENSIN PEPTIDES FORM VOLTAGE-DEPENDENT ION-PERMEABLE CHANNELS IN PLANAR LIPID BILAYER-MEMBRANES [J].