Functionalised pyrrolidinones derived from (S)-pyroglutamic acid

被引：46

作者：

Beard, MJ

Bailey, JH

Cherry, DT

Moloney, MG

Shim, SB

Statham, KA

Bamford, MJ

Lamont, RB

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] GLAXO WELLCOME,MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

TETRAHEDRON | 1996年 / 52卷 / 10期

关键词：

D O I：

10.1016/0040-4020(96)00047-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The generation of the lactam enolate derived from bicyclic lactams 2a-c, prepared from (S)-pyroglutamic acid 1a, and subsequent reaction with a range of electrophiles, is reported. Exo-diastereoselectivity is generally favoured. The deprotection of some of these adducts to give functionalised hydroxymethylpyrrolidinones is readily achieved by simple hemiaminal ether cleavage under acidic conditions.

引用

页码：3719 / 3740

页数：22

共 39 条

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