Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5

被引：92

作者：

Niks, E. H.

Kuks, J. B. M.

Roep, B. O.

Haasnoot, G. W.

Verduijn, W.

Ballieux, B. E. P. B.

De Baets, M. H.

Vincent, A.

Verschuuren, J. J. G. M.

机构：

[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Immunohaematol & Blood Transfus, NL-2300 RC Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Clin Chem, NL-2300 RC Leiden, Netherlands

[4] Univ Groningen, Med Ctr, Dept Neurol, Groningen, Netherlands

[5] Maastricht Univ, Med Ctr, Dept Neurol, Maastricht, Netherlands

[6] Univ Oxford, Dept Clin Neurol, Neurosci Grp, Oxford, England

来源：

NEUROLOGY | 2006年 / 66卷 / 11期

关键词：

D O I：

10.1212/01.wnl.0000218159.79769.5c

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK Ab + MG) and found an association with HLA-DR14-DQ5 ( odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 x 10(-5)). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls ( p = 1.0 x 10(-8)). This association between MuSK Ab + MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab + MG with HLA-B8-DR3.

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页码：1772 / 1774

页数：3

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