Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases

被引：22

作者：

Pan, WT

Liu, H

Xu, YJ

Chen, X

Kim, KH

Milligan, DL

Columbus, J

Hadari, YR

Kussie, P

Wong, WC

Labelle, M

机构：

[1] ImClone Syst Inc, Dept Chem, Brooklyn, NY 11226 USA

[2] ImClone Syst Inc, Dept Prot Sci, New York, NY 10014 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 24期

关键词：

kinase inhibitor; oxazepine; FLT-3; aurora;

D O I：

10.1016/j.bmcl.2005.08.098

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyrimido-oxazepine based sub-micromolar inhibitors (2-4) for Aurora and FLT-3 were designed and synthesized. These preliminary results supported the potential use of pyrimido-oxazepines as a versatile template for developing specific kinase inhibitors. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5474 / 5477

页数：4

共 22 条

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