Flavonoids: Cellular and molecular mechanism of action in glucose homeostasis

被引：76

作者：

Cazarolli, Luisa Helena ^{[1
]}

Zanatta, Leila ^{[1
]}

Alberton, Elga Heloisa ^{[1
]}

Reis Bonorino Figueiredo, Maria Santos ^{[1
]}

Folador, Poliane ^{[1
]}

Damazio, Rosangela Guollo ^{[1
]}

Pizzolatti, Moacir Geraldo ^{[2
]}

Mena Barreto Silva, Fatima Regina ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Bioquim, BR-88040970 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 10期

关键词：

flavonoids; mechanism of action; glycemia; insulin; diabetes;

D O I：

10.2174/138955708785740580

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The purpose of this review is to discuss the cellular and molecular mechanisms of action of flavonoids focusing on carbohydrate metabolism. The beneficial effects of flavonoids have been studied in relation to diabetes mellitus, either through their capacity to avoid glucose absorption or to improve glucose tolerance. Furthermore, flavonoids stimulate glucose uptake in peripheral tissues, regulate the activity and/or expression of the rate-limiting enzymes in the carbohydrate metabolism pathway and act per se as insulin secretagogues or insulin mimetics, probably, by influencing the pleiotropic mechanisms of insulin signaling, to ameliorate the diabetes status.

引用

收藏

页码：1032 / 1038

页数：7

相关论文

共 72 条

[31] Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo [J].

Koyama, Y ;

Abe, K ;

Sano, Y ;

Ishizaki, Y ;

Njelekela, M ;

Shoji, Y ;

Hara, Y ;

Isemura, M .

PLANTA MEDICA, 2004, 70 (11) :1100-1102

[32] Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats [J].

Lee, Jeong-Sook .

LIFE SCIENCES, 2006, 79 (16) :1578-1584

[33] Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin [J].

Li, JM ;

Che, CT ;

Lau, CBS ;

Leung, PS ;

Cheng, CHK .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2006, 38 (5-6) :985-995

[34] Genistein acutely stimulates insulin secretion in pancreatic β-cells through a cAMP-dependent protein kinase pathway [J].

Liu, DM ;

Zhen, W ;

Yang, ZD ;

Carter, JD ;

Si, HW ;

Reynolds, KA .

DIABETES, 2006, 55 (04) :1043-1050

[35] Mediation of β-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats [J].

Liu, IM ;

Liou, SS ;

Cheng, JT .

JOURNAL OF ETHNOPHARMACOLOGY, 2006, 104 (1-2) :199-206

[36] Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats [J].

Liu, IM ;

Liou, SS ;

Lan, TW ;

Hsu, FL ;

Cheng, JT .

PLANTA MEDICA, 2005, 71 (07) :617-621

[37] Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells [J].

Mao, CP ;

Gu, ZL .

ACTA PHARMACOLOGICA SINICA, 2005, 26 (08) :982-986

[38] Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of α-glucosidase action [J].

Matsui, T ;

Kobayashi, M ;

Hayashida, S ;

Matsumoto, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2002, 66 (03) :689-692

[39] Contrasting effects of puerarin and daidzin on glucose homeostasis in mice [J].

Meezan, E ;

Meezan, EM ;

Jones, K ;

Moore, R ;

Barnes, S ;

Prasain, JK .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (22) :8760-8767

[40] Insulinomimetic effects of myricetin on lipogenesis and glucose transport in rat adipocytes but not glucose transporter translocation [J].

Ong, KC ;

Khoo, HE .

BIOCHEMICAL PHARMACOLOGY, 1996, 51 (04) :423-429

← 1 2 3 4 5 6 7 8 →