Segmental duplications and the evolution of the primate genome

被引：302

作者：

Samonte, RV ^{[1
]}

Eichler, EE

机构：

[1] Case Western Reserve Univ, Sch Med, Ctr Human Genet, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Ctr Human Genet, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland, OH 44106 USA

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg705

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Initial human genome sequence analysis has revealed large segments of nearly identical sequence in particular chromosomal regions. The recent origin of these segments and their abundance (similar to5%) has challenged investigators to elucidate their underlying mechanism and role in primate genome evolution. Although the precise fraction is unknown, some of these duplicated segments have recently been shown to be associated with rapid gene innovation and chromosomal rearrangement in the genomes of man and the great apes.

引用

页码：65 / 72

页数：8

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