Human immune responses to the UK human anthrax vaccine

被引：21

作者：

Baillie, LWJ

Fowler, K

Turnbull, PCB

机构：

[1] DERA, Chem & Biol Def Sector, Salisbury SP4 0JG, Wilts, England

[2] Ctr Appl Microbiol & Res, Salisbury SP4 0JG, Wilts, England

来源：

JOURNAL OF APPLIED MICROBIOLOGY | 1999年 / 87卷 / 02期

关键词：

D O I：

10.1046/j.1365-2672.1999.00899.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The IgG anti-protective antigen subclass antibody response of individuals who had been infected with anthrax was compared with that of healthy individuals immunized with the UK licensed anthrax vaccine. The predominant subclass in both groups was IgG1. In addition, IgG3 was seen in convalescent serum while vaccinees produced IgG2, IgG3 and IgG-C subclass. The significance of these results is discussed. Further work is required to determine the role of antibodies in mediating protective immunity in man.

引用

页码：306 / 308

页数：3

共 10 条

[1]

Baillie L. W. J., 1996, SALISBURY MED B S, V87, P133

[2]

DARLOW HM, 1956, LANCET, V11, P476

[3] Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen [J].