Treatment of severe thrombocytopenia with IL-11 in children with Wiskott-Aldrich syndrome

被引：4

作者：

Braithwaite, K

Abu-Ghosh, A

Anderson, L

Cairo, MS

机构：

[1] Columbia Univ, Childrens Hosp New York, Dept Pediat, New York, NY 10032 USA

[2] Georgetown Univ, Med Ctr, Dept Pediat, Washington, DC 20007 USA

[3] Georgetown Univ, Med Ctr, Lombardi Canc Ctr, Washington, DC 20007 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2002年 / 24卷 / 04期

关键词：

Wiskott-Aldrich syndrome; IL-11; thrombocytopenia; platelets; bone marrow transplantation; stem cell transplantation;

D O I：

10.1097/00043426-200205000-00022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This report examines the safety and efficacy of IL-11 treating severe thrombocytopenia secondary to Wiskott-Aldrich syndrome in two pediatric patients before allogeneic stem cell transplantation (SCT). Both patients had a substantial increase in their platelet counts and a decrease in bleeding episodes and platelet transfusions. The median platelet count increased from 32,000/mm(3) to 64,000/mm(3). Each subsequently received allogeneic SCT; 1 year after transplantation, both are reconstituted with 100%, donor hematopoietic stein cells with sustained normal platelet counts (>200 K/mm(3)). Larger studies are required to confirm this observation of the safety and efficacy of IL-11 in this setting.

引用

页码：323 / 326

页数：4