The IMGT/HLA database

被引：135

作者：

Robinson, James ^{[1
]}

Waller, Matthew J. ^{[1
]}

Fail, Sylvie C. ^{[1
]}

McWilliam, Hamish ^{[2
]}

Lopez, Rodrigo ^{[2
]}

Parham, Peter ^{[3
]}

Marsh, Steven G. E. ^{[1
,4
]}

机构：

[1] Royal Free Hosp, Anthony Nolan Res Inst, London NW3 2QG, England

[2] EMBL Outstn European Bioinformat Inst, External Serv, Cambridge CB10 1SD, England

[3] Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA

[4] UCL, Inst Canc, London NW3 2QG, England

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

I NUCLEOTIDE-SEQUENCES; REGION SEQUENCES; HLA SYSTEM; NOMENCLATURE;

D O I：

10.1093/nar/gkn662

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is 10 years since the IMGT/HLA database was released, providing the HLA community with a searchable repository of highly curated HLA sequences. The HLA complex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and are highly polymorphic. The naming of these HLA genes and alleles, and their quality control is the responsibility of the WHO Nomenclature Committee for Factors of the HLA System. Through the work of the HLA Informatics Group and in collaboration with the European Bioinformatics Institute, we are able to provide public access to this data through the website http://www.ebi.ac.uk/imgt/hla/. The first release contained 964 sequences, the most recent release 3300 sequences, with around 450 new sequences been added each year. The tools provided on the website have been updated to allow more complex alignments, which include genomic sequence data, as well as the development of tools for probe and primer design and the inclusion of data from the HLA Dictionary. Regular updates to the website ensure that new and confirmatory sequences are dispersed to the HLA community, and the wider research and clinical communities.

引用

页码：D1013 / D1017

页数：5

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