Signal transduction - Feedback from inhibitory SMADs

被引：54

作者：

Whitman, M

机构：

[1] Harvard Medical School,the Department of Cell Biology

来源：

NATURE | 1997年 / 389卷 / 6651期

关键词：

D O I：

10.1038/39202

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many biological processes involve signalling through the transforming growth factor-b (TGF-β) superfamily of proteins. In some pathways, TGF-b signals are mediated through the SMAD family of signal transducers. Smads 1, 2, 3 and 5 are activated when members of the TGF-b family bind their receptors, leading to association with Smad4 and a transcriptional response. Three groups now independently show that two new SMADs (Smads 6 and 7) and a Drosophila homologue inhibit this signalling process.

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收藏

页码：549 / 551

页数：3

相关论文

共 11 条

[1] Transforming growth factor-beta: The breaking open of a black box [J].

Alevizopoulos, A ;

Mermod, N .

BIOESSAYS, 1997, 19 (07) :581-591

[2] Smad4 and FAST-1 in the assembly of activin-responsive factor [J].

Chen, X ;

Weisberg, E ;

Fridmacher, V ;

Watanabe, M ;

Naco, G ;

Whitman, M .

NATURE, 1997, 389 (6646) :85-89

[3] The MAD-related protein Smad7 associates with the TGF beta receptor and functions as an antagonist of TGF beta signaling [J].

Hayashi, H ;

Abdollah, S ;

Qiu, YB ;

Cai, JX ;

Xu, YY ;

Grinnell, BW ;

Richardson, MA ;

Topper, JN ;

Gimbrone, MA ;

Wrana, JL ;

Falb, D .

CELL, 1997, 89 (07) :1165-1173

[4] Smad6 inhibits signalling by the TGF-beta superfamily [J].

Imamura, T ;

Takase, M ;

Nishihara, A ;

Oeda, E ;

Hanai, J ;

Kawabata, M ;

Miyazono, K .

NATURE, 1997, 389 (6651) :622-626

[5] Drosophila MAD binds to DNA and directly mediates activation of vestigial by decapentaplegic [J].

Kim, J ;

Johnson, K ;

Chen, HJ ;

Carroll, S ;

Laughon, A .

NATURE, 1997, 388 (6639) :304-308

[6] TGF-beta signalling through the Smad pathway [J].

Massague, J ;

Hata, A ;

Liu, F .

TRENDS IN CELL BIOLOGY, 1997, 7 (05) :187-192

[7] Identification of Smad7, a TGF beta-inducible antagonist of TGF-beta signalling [J].

Nakao, A ;

Afrakhte, M ;

Moren, A ;

Nakayama, T ;

Christian, JL ;

Heuchel, R ;

Itoh, S ;

Kawabata, N ;

Heldin, NE ;

Heldin, CH ;

tenDijke, P .

NATURE, 1997, 389 (6651) :631-635

[8] Morphogens and pattern formation [J].

Neumann, C ;

Cohen, S .

BIOESSAYS, 1997, 19 (08) :721-729

[9]

RAFTERY LA, 1995, GENETICS, V139, P241

[10] Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium [J].

Topper, JN ;

Cai, JX ;

Qiu, YB ;

Anderson, KR ;

Xu, YY ;

Deeds, JD ;

Feeley, R ;

Gimeno, CJ ;

Woolf, EA ;

Tayber, O ;

Mays, GG ;

Sampson, BA ;

Schoen, FJ ;

Gimbrone, MA ;

Falb, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9314-9319