Transforming growth factor-beta: The breaking open of a black box

被引：87

作者：

Alevizopoulos, A ^{[1
]}

Mermod, N ^{[1
]}

机构：

[1] ECOLE POLYTECH FED LAUSANNE,LAB MOL BIOTECHNOL,CTR BIOTECHNOL,UNIL,EPFL,DC,IGC,CH-1015 LAUSANNE,SWITZERLAND

来源：

BIOESSAYS | 1997年 / 19卷 / 07期

关键词：

D O I：

10.1002/bies.950190709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor-beta (TGF-beta) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF-beta function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF-beta action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF-beta signal transduction with respect to the regulation of gene expression, the control of cell phenotype and the potential usage of TGF-beta for the treatment of human diseases.

引用

收藏

页码：581 / 591

页数：11

相关论文

共 93 条

[1] A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3 [J].

Alevizopoulos, A ;

Dusserre, Y ;

TsaiPflugfelder, M ;

vonderWeid, T ;

Wahli, W ;

Mermod, N .

GENES & DEVELOPMENT, 1995, 9 (24) :3051-3066

[2] Antagonistic regulation of a proline-rich transcription factor by transforming growth factor beta and tumor necrosis factor alpha [J].

Alevizopoulos, A ;

Mermod, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (47) :29672-29681

[3] Chimeric granulocyte/macrophage colony-stimulating factor transforming growth factor-beta (TGF-beta) receptors define a model system for investigating the role of homomeric and heteromeric receptors in TGF-beta signaling [J].

Anders, RA ;

Leof, EB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (36) :21758-21766

[4]

ATFI A, 1994, J BIOL CHEM, V269, P30688

[5] Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling [J].

Atfi, A ;

Djelloul, S ;

Chastre, E ;

Davis, RR ;

Gespach, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (03) :1429-1432

[6] IDENTIFICATION OF HUMAN ACTIVIN AND TGF-BETA TYPE-I RECEPTORS THAT FORM HETEROMERIC KINASE COMPLEXES WITH TYPE-II RECEPTORS [J].

ATTISANO, L ;

CARCAMO, J ;

VENTURA, F ;

WEIS, FMB ;

MASSAGUE, J ;

WRANA, JL .

CELL, 1993, 75 (04) :671-680

[7] Transforming growth factor-beta 1 modulates p107 function in myeloid cells - Correlation with cell cycle progression [J].

Bang, OS ;

Ruscetti, FW ;

Lee, MH ;

Kim, SJ ;

BirchenallRoberts, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) :7811-7819

[8]

BARLAT I, 1995, ONCOGENE, V11, P1309

[9] COMPLEX REGULATION OF TRANSFORMING GROWTH FACTOR-BETA-1, FACTOR-BETA-2, AND FACTOR-BETA-3 MESSENGER-RNA EXPRESSION IN MOUSE FIBROBLASTS AND KERATINOCYTES BY TRANSFORMING GROWTH FACTOR-BETA-1 AND FACTOR-BETA-2 [J].

BASCOM, CC ;

WOLFSHOHL, JR ;

COFFEY, RJ ;

MADISEN, L ;

WEBB, NR ;

PURCHIO, AR ;

DERYNCK, R ;

MOSES, HL .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (12) :5508-5515

[10] A TRANSFORMING GROWTH-FACTOR-BETA TYPE-I RECEPTOR THAT SIGNALS TO ACTIVATE GENE-EXPRESSION [J].

BASSING, CH ;

YINGLING, JM ;

HOWE, DJ ;

WANG, TW ;

HE, WW ;

GUSTAFSON, ML ;

SHAH, P ;

DONAHOE, PK ;

WANG, XF .

SCIENCE, 1994, 263 (5143) :87-89

← 1 2 3 4 5 6 7 8 9 10 →