Transforming growth factor-beta: The breaking open of a black box

被引：87

作者：

Alevizopoulos, A ^{[1
]}

Mermod, N ^{[1
]}

机构：

[1] ECOLE POLYTECH FED LAUSANNE,LAB MOL BIOTECHNOL,CTR BIOTECHNOL,UNIL,EPFL,DC,IGC,CH-1015 LAUSANNE,SWITZERLAND

来源：

BIOESSAYS | 1997年 / 19卷 / 07期

关键词：

D O I：

10.1002/bies.950190709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor-beta (TGF-beta) and its related proteins regulate broad aspects of body development, including cell proliferation, differentiation, apoptosis and gene expression, in various organisms. Deregulated TGF-beta function has been causally implicated in the generation of human fibrotic disorders and in tumor progression. Nevertheless, the molecular mechanisms of TGF-beta action remained essentially unknown until recently. Here, we discuss recent progress in our understanding of the mechanism of TGF-beta signal transduction with respect to the regulation of gene expression, the control of cell phenotype and the potential usage of TGF-beta for the treatment of human diseases.

引用

页码：581 / 591

页数：11

共 93 条

[51] POTENTIAL ROLE OF WAF1/CIP1/P21 AS A MEDIATOR OF TGF-BETA CYTOINHIBITORY EFFECT [J].