共 64 条
Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila
被引:42
作者:
Bessa, J
Casares, F
[1
]
机构:
[1] Univ Pablo de Olavide, CSIC, Ctr Andaluz Biol Desarrollo, E-41013 Seville, Spain
[2] Univ Porto, Inst Mol & Cellular Biol, P-4150180 Oporto, Portugal
来源:
DEVELOPMENT
|
2005年
/
132卷
/
22期
关键词:
Drosophila;
eye disc;
eye determination;
teashirt;
wingless;
decapentaplegic;
eyes absent;
homothorax;
atonal;
D O I:
10.1242/dev.02082
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
In Drosophila, the eye primordium, is specified as a subdomain of the larval eye disc. Here, we show that the Zn-finger transcription factor teashirt (tsh) marks the region of the early eye disc where the eye primordiurn will form. Moreover, tsh misexpression directs eye primordium formation in disc regions normally destined to form head capsule, something the eye selector genes eyeless (ey) and twin of eyeless (toy) are unable to do on their own. We present evidence that tsh induces eye specification, at least in part, by allowing the activation of eye specification genes by the wingless (wg) and decapentaplegic (dpp) signaling pathways. Under these conditions, though, terminal eye differentiation proceeds only if tsh expression is transient.
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页码:5011 / 5020
页数:10
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