Ligands for the investigation of 5-HT autoreceptor function

被引：53

作者：

Roberts, C ^{[1
]}

Price, GW ^{[1
]}

Middlemiss, DN ^{[1
]}

机构：

[1] GlaxoSmithKline, Neurosci Res, Harlow, Essex, England

来源：

BRAIN RESEARCH BULLETIN | 2001年 / 56卷 / 05期

关键词：

5-HT1A; 5-HT1B; 5-HT1D; 5-HT1F; 5-HT5A; 5-HT7; SB-272183; SB-224289; SB-236057; SB-269970;

D O I：

10.1016/S0361-9230(01)00628-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The existence of multiple 5-HT autoreceptors in the central nervous system is now firmly established and they have been pharmacologically identified as belonging to the 5-HT1A, 5-HT1B, and 5-HT1D receptor subtypes. In addition, 5-HT1F, 5-HT5A, and 5-HT7 receptors remain as potential candidates for additional autoreceptors. The emergence of selective ligands, such as SB-224289 (5-HT1B receptor antagonist), BRL 15572 (5-HT1D receptor antagonist), GR 127935 (a mixed 5-HT1B/1D receptor antagonist), LY 334370 (5-HT1F receptor agonist), and SB-269970 (5-HT7 receptor antagonist), has aided the characterisation of 5-HT autoreceptors and has highlighted the complexity of mechanisms which modulate the release of 5-HT. (C) 2001 Elsevier Science Inc.

引用

页码：463 / 469

页数：7

共 82 条

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