The functions of Ca2+ in bacteria:: a role for EF-hand proteins?

被引:158
作者
Michiels, J [1 ]
Xi, CW [1 ]
Verhaert, J [1 ]
Vanderleyden, J [1 ]
机构
[1] Ctr Microbial & Plant Genet, B-3001 Heverlee, Belgium
关键词
D O I
10.1016/S0966-842X(01)02284-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In bacteria, Ca2+ is implicated in a wide variety of cellular processes, including the cell cycle and cell division. Dedicated influx and efflux systems tightly control the low cytoplasmic Ca2+ levels in prokaryotes. Additionally, the growing number of proteins containing various Ca2+-binding motifs supports the importance of Ca2+, which controls various protein functions by affecting protein stability, enzymatic activity or signal transduction. The existence of calmodulin-like proteins (containing EF-hand motifs) in bacteria is a long-standing hypothesis. Analysis of the prokaryotic protein sequences available in the databases has revealed the presence of several calmodulin-like proteins containing two or more authentic EF-hand motifs, suggesting that calmodulin-like proteins could be involved in Ca2+ regulation in bacteria.
引用
收藏
页码:87 / 93
页数:7
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