A Newly Identified Bocavirus Species in Human Stool

被引:256
作者
Kapoor, Amit [1 ,2 ]
Slikas, Elizabeth [1 ,2 ]
Simmonds, Peter [3 ]
Chieochansin, Thaweesak [3 ]
Naeem, Asif [4 ]
Shaukat, Shahzad [4 ]
Alam, Muhammad Masroor [4 ]
Sharif, Salmaan [4 ]
Angez, Mehar [4 ]
Zaidi, Sohail [4 ]
Delwart, Eric [1 ,2 ]
机构
[1] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94118 USA
[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
[3] Univ Edinburgh, Ctr Infect Dis, Edinburgh, Midlothian, Scotland
[4] Natl Inst Hlth, Dept Virol, Islamabad, Pakistan
关键词
POLYMERASE-CHAIN-REACTION; HUMAN PARVOVIRUS PARV4; ACUTE GASTROENTERITIS; MOLECULAR EPIDEMIOLOGY; BOVINE PARVOVIRUS; VIRUS EVOLUTION; BLOOD-DONORS; HUMAN PLASMA; CHILDREN; INFECTION;
D O I
10.1086/595831
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Viral metagenomic analysis was used to identify a previously uncharacterized parvovirus species, "HBoV2," whose closest phylogenetic relative is the human bocavirus (HBoV). HBoV2 has a genomic organization identical to that of HBoV but has only 78%, 67%, and 80% identity, respectively, with the latter's NS1, NP1, and VP1/VP2 proteins. The study used polymerase chain reaction to detect HBoV2 sequences in 5 of 98 stool samples from Pakistani children and in 3 of 699 stool samples from Edinburgh. Nearly-full-length genome sequencing revealed the presence of 3 HBoV2 genotypes and evidence of recombination between genotypes. Further studies are necessary to identify anatomical sites of HBoV2 replication and potential associations with clinical symptoms or disease.
引用
收藏
页码:196 / 200
页数:5
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