Common Therapeutic Targets in Cardiometabolic Disease

被引：15

作者：

Fredman, Gabrielle

Ozcan, Lale

Tabas, Ira ^{[1
]}

机构：

[1] Columbia Univ, Dept Med, New York, NY 10032 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 239期

关键词：

ENDOPLASMIC-RETICULUM STRESS; INSULIN SENSITIVITY; ER STRESS; IN-VIVO; ATHEROSCLEROSIS; MICE; APOPTOSIS; OBESITY; LIVER; INFLAMMATION;

D O I：

10.1126/scitranslmed.3008908

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The interactions between cardiovascular disease (CVD) and insulin resistance syndromes suggest the possibility of joint targets for cardiometabolic research. The best drugs would go beyond minimizing adverse effects and have protective actions against both metabolic disease and CVD. In this perspective, we will outline a few examples in which a deep mechanistic understanding of the many cellular pathways that contribute to type 2 diabetes and CVD, regardless of cell type, have resulted in common upstream pathogenic pathways that can be therapeutically targeted.

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