Evidence for Cardiomyocyte Renewal in Humans

被引：2259

作者：

Bergmann, Olaf ^{[1
]}

Bhardwaj, Ratan D. ^{[1
]}

Bernard, Samuel ^{[2
]}

Zdunek, Sofia ^{[1
]}

Barnabe-Heider, Fanie ^{[1
]}

Walsh, Stuart ^{[3
]}

Zupicich, Joel ^{[1
]}

Alkass, Kanar ^{[4
]}

Buchholz, Bruce A. ^{[5
]}

Druid, Henrik ^{[4
]}

Jovinge, Stefan ^{[3
,6
]}

Frisen, Jonas ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

[2] Univ Lyon 1, Inst Camille Jordan, CNRS, UMR5208, F-69622 Villeurbanne, France

[3] Lund Univ, Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, SE-22184 Lund, Sweden

[4] Karolinska Inst, Dept Forens Med, SE-17177 Stockholm, Sweden

[5] Lawrence Livermore Natl Lab, Ctr Accelerator Mass Spectrometry, Livermore, CA 94551 USA

[6] Univ Lund Hosp, Dept Cardiol, SE-22185 Lund, Sweden

来源：

SCIENCE | 2009年 / 324卷 / 5923期

基金：

瑞典研究理事会; 加拿大健康研究院;

关键词：

CARDIAC MYOCYTES; NUCLEAR TESTS; HUMAN HEARTS; CELLS; HYPERTROPHY; PROGENITORS; ORIGINS; C-14;

D O I：

10.1126/science.1164680

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

引用

页码：98 / 102

页数：5

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