Modification of the extracellular matrix following myocardial infarction monitored by FTIR spectroscopy

被引：87

作者：

Liu, KZ

Jackson, M

Sowa, MG

Ju, HS

Dixon, IMC

Mantsch, HH

机构：

[1] NATL RES COUNCIL CANADA,INST BIODIAGNOST,WINNIPEG,MB R3B 1Y6,CANADA

[2] UNIV MANITOBA,ST BONIFACE GEN HOSP,RES CTR,DIV CARDIOVASC SCI,WINNIPEG,MB,CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1996年 / 1315卷 / 02期

关键词：

collagen; extracellular matrix; FTIR spectroscopy; heart failure; myocardial infarction; near infrared spectroscopy;

D O I：

10.1016/0925-4439(95)00118-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comparison of mid- and near-infrared spectra of control and infarcted rat ventricular tissue reveals the presence of absorptions in infarcted tissue which are highly characteristic of collagen, indicating large scale deposition of type I collagen in the myocardium following infarction. These results demonstrate that IR spectroscopy may be used to rapidly monitor the modifications of the extracellular matrix associated with myocardial infarction.

引用

页码：73 / 77

页数：5

共 11 条

[1] NITRENDIPINE BINDING IN CONGESTIVE HEART-FAILURE DUE TO MYOCARDIAL-INFARCTION [J].