Modification of the extracellular matrix following myocardial infarction monitored by FTIR spectroscopy

被引:87
作者
Liu, KZ
Jackson, M
Sowa, MG
Ju, HS
Dixon, IMC
Mantsch, HH
机构
[1] NATL RES COUNCIL CANADA,INST BIODIAGNOST,WINNIPEG,MB R3B 1Y6,CANADA
[2] UNIV MANITOBA,ST BONIFACE GEN HOSP,RES CTR,DIV CARDIOVASC SCI,WINNIPEG,MB,CANADA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1996年 / 1315卷 / 02期
关键词
collagen; extracellular matrix; FTIR spectroscopy; heart failure; myocardial infarction; near infrared spectroscopy;
D O I
10.1016/0925-4439(95)00118-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Comparison of mid- and near-infrared spectra of control and infarcted rat ventricular tissue reveals the presence of absorptions in infarcted tissue which are highly characteristic of collagen, indicating large scale deposition of type I collagen in the myocardium following infarction. These results demonstrate that IR spectroscopy may be used to rapidly monitor the modifications of the extracellular matrix associated with myocardial infarction.
引用
收藏
页码:73 / 77
页数:5
相关论文
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