CJ-15,801, a novel antibiotic from a fungus, Seimatosporium sp.

被引：39

作者：

Sugie, Y ^{[1
]}

Dekker, KA

Hirai, H

Ichiba, T

Ishiguro, M

Shiomi, Y

Sugiura, A

Brennan, L

Duignan, J

Huang, LH

Sutcliffe, J

Kojima, Y

机构：

[1] Pfizer Pharmaceut Inc, Nagoya Labs, PGRD, Exploratory Med Sci, Taketoyo, Aichi 4702393, Japan

[2] Pfizer Inc, Groton Labs, PGRD, Groton, CT 06340 USA

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 12期

关键词：

D O I：

10.7164/antibiotics.54.1060

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel antibiotic, CJ-15,801 (1), was isolated from the fermentation broth of a fungus, Seimatosporium sp. CL28611. The structure was determined to be a pantothenic acid analog having an a,,B-unsaturated carboxylic acid moiety by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant (MDR) Staphylococcus aureus strains with MIC ranging from 6.25 to 50 mug/ml.

引用

页码：1060 / 1065

页数：6

共 14 条

[1] AMACHI T, 1970, TETRAHEDRON LETT, P4871
[2] [Anonymous], 1980, COELOMYCETES FUNGI I
[3] GEOTRICHUM-CANDIDUM
CARMICHAEL, JW
[J]. MYCOLOGIA, 1957, 49 (06) : 820 - 830
[4] FURUKAWA Y, 1986, Tohoku Journal of Agricultural Research, V36, P155
[5] Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
Hiramatsu, K
Aritaka, N
Hanaki, H
Kawasaki, S
Hosoda, Y
Hori, S
Fukuchi, Y
Kobayashi, I
[J]. LANCET, 1997, 350 (9092) : 1670 - 1673
[6] Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility
Hiramatsu, K
Hanaki, H
Ino, T
Yabuta, K
Oguri, T
Tenover, FC
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (01) : 135 - 136
[7] KUHN R, 1940, CHEM BER, V73, P971
[8] National Committee for Clinical Laboratory Standards, 1997, METH DIL ANT SUSC TE
[9] Raper K. B., 1965, GENUS ASPERGILLUS, P686
[10] Ridgway R, 1912, COLOR STANDARDS COLO, P1

← 1 2 →