CJ-15,801, a novel antibiotic from a fungus, Seimatosporium sp.

被引：39

作者：

Sugie, Y ^{[1
]}

Dekker, KA

Hirai, H

Ichiba, T

Ishiguro, M

Shiomi, Y

Sugiura, A

Brennan, L

Duignan, J

Huang, LH

Sutcliffe, J

Kojima, Y

机构：

[1] Pfizer Pharmaceut Inc, Nagoya Labs, PGRD, Exploratory Med Sci, Taketoyo, Aichi 4702393, Japan

[2] Pfizer Inc, Groton Labs, PGRD, Groton, CT 06340 USA

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 12期

关键词：

D O I：

10.7164/antibiotics.54.1060

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel antibiotic, CJ-15,801 (1), was isolated from the fermentation broth of a fungus, Seimatosporium sp. CL28611. The structure was determined to be a pantothenic acid analog having an a,,B-unsaturated carboxylic acid moiety by spectroscopic analyses. The compound inhibits the growth of multi-drug resistant (MDR) Staphylococcus aureus strains with MIC ranging from 6.25 to 50 mug/ml.

引用

页码：1060 / 1065

页数：6

共 14 条

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