Berberine: New perspectives for old remedies

被引：380

作者：

Tillhon, Micol ^{[1
]}

Guaman Ortiz, Luis M. ^{[1
,2
]}

Lombardi, Paolo ^{[3
]}

Scovassi, A. Ivana ^{[1
]}

机构：

[1] IGM CNR, I-27100 Pavia, Italy

[2] UTPL, Loja, Ecuador

[3] Naxospharma, I-20026 Novate Milanese, Italy

来源：

BIOCHEMICAL PHARMACOLOGY | 2012年 / 84卷 / 10期

关键词：

Apoptosis; Autophagy; Berberine; Cancer; Isoquinoline alkaloid; DNA-BINDING AFFINITIES; INDUCED GROWTH-INHIBITION; AUTOPHAGIC CELL-DEATH; LEUKEMIA HL-60 CELLS; BREAST-CANCER CELLS; INDUCED APOPTOSIS; TOPOISOMERASE-I; DOWN-REGULATION; ISOQUINOLINE ALKALOIDS; NATURAL-PRODUCTS;

D O I：

10.1016/j.bcp.2012.07.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chemical compounds derived from plants have been used since the origin of human beings to counteract a number of diseases. Among them, the natural isoquinoline alkaloid berberine has been employed in Ayurvedic and Chinese Medicine for hundreds of years with a wide range of pharmacological and biochemical effects. More recently, a growing body of reports supports the evidence that berberine has anticancer effects, being able to block the proliferation of and to kill cancer cells. This review addresses the properties and therapeutic use of berberine and focuses on the recent advances as promising anticancer drug lead. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1260 / 1267

页数：8

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