Interaction of the hypocretins with neurotransmitters in the nucleus accumbens

被引：71

作者：

Martin, G

Fabre, W

Siggins, GR

de Lecea, L

机构：

[1] Scripps Res Inst, Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA

来源：

REGULATORY PEPTIDES | 2002年 / 104卷 / 1-3期

关键词：

orexins; steep; GABA; glycine; patch clamp; NMDA;

D O I：

10.1016/S0167-0115(01)00354-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The hypocretins (hcrt1 and hcrt2), also known as orexins, are two neuropeptides derived from the same precursor, expressed in a few thousand cells in the lateral hypothalamus. Hypocretin-containing cells project throughout the brain, including ascending projections to the olfactory bulb and cerebral cortex, through the medial septum and the nucleus accumbens, Here, we have studied the interactions of the hypocretins with different neurotransmitters by patch clamp recording of acutely dissociated cells from the nucleus accumbens. Application of hcrt1 or hcrt2 decreased postsynaptic NMDA currents, enhanced GABA currents but did not affect glycine-activated conductances. Our results strongly suggest that the hypocretin peptides may be inhibitory peptides, probably via binding hcrt receptor 2. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：111 / 117

页数：7

共 43 条

[1]

Bourgin P, 2000, J NEUROSCI, V20, P7760

[2] Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat [J].

Brown, RE ;

Sergeeva, O ;

Eriksson, KS ;

Haas, HL .

NEUROPHARMACOLOGY, 2001, 40 (03) :457-459

[3] Narcolepsy in orexin knockout mice:: Molecular genetics of sleep regulation [J].

Chemelli, RM ;

Willie, JT ;

Sinton, CM ;

Elmquist, JK ;

Scammell, T ;

Lee, C ;

Richardson, JA ;

Williams, SC ;

Xiong, YM ;

Kisanuki, Y ;

Fitch, TE ;

Nakazato, M ;

Hammer, RE ;

Saper, CB ;

Yanagisawa, M .

CELL, 1999, 98 (04) :437-451

[4]

CHOMCZYNSKI P, 1993, BIOTECHNIQUES, V15, P532

[5]

Chomczynski P, 1993, BIOTECHNIQUES, V15, P536

[6] Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor [J].

Darker, JG ;

Porter, RA ;

Eggleston, DS ;

Smart, D ;

Brough, SJ ;

Sabido-David, C ;

Jerman, JC .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (05) :737-740

[7] Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems [J].

Date, Y ;

Ueta, Y ;

Yamashita, H ;

Yamaguchi, H ;

Matsukura, S ;

Kangawa, K ;

Sakurai, T ;

Yanagisawa, M ;

Nakazato, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) :748-753

[8] The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity [J].

De Lecea, L ;

Kilduff, TS ;

Peyron, C ;

Gao, XB ;

Foye, PE ;

Danielson, PE ;

Fukuhara, C ;

Battenberg, ELF ;

Gautvik, VT ;

Bartlett, FS ;

Frankel, WN ;

van den Pol, AN ;

Bloom, FE ;

Gautvik, KM ;

Sutcliffe, JG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) :322-327

[9] CLONING AND EXPRESSION OF AN ADENYLYL CYCLASE LOCALIZED TO THE CORPUS STRIATUM [J].

GLATT, CE ;

SNYDER, SH .

NATURE, 1993, 361 (6412) :536-538

[10] Orexin A activates locus coeruleus cell firing and increases arousal in the rat [J].

Hagan, JJ ;

Leslie, RA ;

Patel, S ;

Evans, ML ;

Wattam, TA ;

Holmes, S ;

Benham, CD ;

Taylor, SG ;

Routledge, C ;

Hemmati, P ;

Munton, RP ;

Ashmeade, TE ;

Shah, AS ;

Hatcher, JP ;

Hatcher, PD ;

Jones, DNC ;

Smith, MI ;

Piper, DC ;

Hunter, AJ ;

Porter, RA ;

Upton, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10911-10916

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