Characterization of the expression of the ALK receptor tyrosine kinase in mice

被引：118

作者：

Vernersson, E

Khoo, NKS

Henriksson, ML

Roos, G

Palmer, RH

Hallberg, B

机构：

[1] Umea Univ, Dept Med Biosci Pathol, S-90187 Umea, Sweden

[2] Umea Univ, Umea Ctr Mol Pathogenesis, S-90187 Umea, Sweden

[3] Umea Univ, Umea Transgene Core Facil, S-90187 Umea, Sweden

来源：

GENE EXPRESSION PATTERNS | 2006年 / 6卷 / 05期

关键词：

receptor tyrosine kinase; anaplastic lymphoma kinase; oesophagus; CNS; PNS; anaplastic large cell lymphoma;

D O I：

10.1016/j.modgep.2005.11.006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase, was first described as the fusion product causing a subtype of non-Hodgkin's lymphoma. To date Alk has been reported to be mainly expressed in CNS and other parts of the brain. Here we describe an extensive characterization of the mRNA and protein expression of ALK during mouse development. We show that mRNA and ALK protein show overlapping expressing patterns in specific regions of the central and the peripheral nervous systems. Furthermore, ALK is also expressed in the eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach and midgut but not the hindgut. Expression of ALK is also found in testis and ovary. (c) 2005 Elsevier B.V. All rights reserved.

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收藏

页码：448 / 461

页数：14

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