PI3K/Akt: getting it right matters

被引:576
作者
Franke, T. F. [1 ,2 ]
机构
[1] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Pharmacol, New York, NY 10016 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
Akt/PKB; PI3K/PTEN; PDK2; mTORC; Akt-interacting proteins; human disease;
D O I
10.1038/onc.2008.313
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.
引用
收藏
页码:6473 / 6488
页数:16
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