The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice

被引:42
作者
Dendrou, Calliope A. [1 ]
Wicker, Linda S. [1 ]
机构
[1] Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res,Juvenile Diabet Res Fdn, Wellcome Trust Diabet & Inflammat Lab,Dept Med Ge, Cambridge CB2 OXY, England
基金
英国惠康基金;
关键词
Type; 1; diabetes; NOD mice; CD25; IL-2RA; IL-2;
D O I
10.1007/s10875-008-9237-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although the interleukin-2 (IL-2)/IL-2R signaling pathway has been the focus of numerous studies, certain aspects of its molecular regulation are not well characterized, especially ill non-T cells, and a more complete understanding of the pathway is necessary to discern the functional basis of the genetic association between the IL-2-IL-21 and IL-2RA/CD25 gene regions and T1D in humans. Genetic variation in these regions may promote T1D Susceptibility by influencing transcription and/or splicing and, hence, IL-2 and IL-2RA/CD25 expression at the protein level in different immune cell subsets; thus, there is a need to establish links between the genetic variation and immune cell phenotypes and functions in humans, which can be further investigated and validated in mouse models. The detection and characterization of genetically determined immunopheno-types should aid ill elucidating disease mechanisms and may enable future monitoring of disease initiation and progression in prediabetic Subjects and of responses to therapeutic intervention.
引用
收藏
页码:685 / 696
页数:12
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