The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences

被引：261

作者：

Humbert, M ^{[1
]}

Menz, G ^{[1
]}

Ying, S ^{[1
]}

Corrigan, CJ ^{[1
]}

Robinson, DS ^{[1
]}

Durham, SR ^{[1
]}

Kay, AB ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Allergy & Clin Immunol, Natl Heart & Lung Inst, London SW3 6LY, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 11期

关键词：

D O I：

10.1016/S0167-5699(99)01535-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intrinsic asthma shows no clinical or serological evidence of IgE-mediated allergy to common environmental agents. Similar to extrinsic asthma, bronchial biopsies from such patients show enhanced expression of Th2-type cytokines, CC chemokines and I epsilon/C epsilon compared with controls. These findings suggest that there might be local IgE production directed against unknown antigens, possibly of viral origin or even autoantigens, in this important clinically distinct variant of the disease.

引用

页码：528 / 533

页数：6

共 36 条

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