Defensins in innate antiviral immunity

被引：384

作者：

Klotman, ME ^{[1
]}

Chang, TL ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY 10029 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 06期

关键词：

D O I：

10.1038/nri1860

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defensins are small antimicrobial peptides that are produced by leukocytes and epithelial cells, and that have an important role in innate immunity. Recent advances in understanding the mechanisms of the antiviral action(s) of defensins indicate that they have a dual role in antiviral defence, acting directly on the virion and on the host cell. This Review focuses on the antiviral activities and mechanisms of action of mammalian defensins, and on the clinical relevance of these activities. Understanding the complex function of defensins in innate immunity against viral infection has implications for the prevention and treatment of viral disease.

引用

页码：447 / 456

页数：10

共 111 条

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