Characterization of naive, memory and effector CD8+T cells: effect of age

被引：67

作者：

Gupta, S ^{[1
]}

Bi, RF ^{[1
]}

Su, K ^{[1
]}

Yel, L ^{[1
]}

Chiplunkar, S ^{[1
]}

Gollapudi, S ^{[1
]}

机构：

[1] Univ Calif Irvine, Div Basic & Clin Immunol, Cellular & Mol Immunol Labs, Irvine, CA 92697 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2004年 / 39卷 / 04期

关键词：

memory T cells; effector T cells; apoptosis; co-stimulation; inducible co-stimulatory molecule; TNF receptors; Bcl-2; Bcl-6;

D O I：

10.1016/j.exger.2003.08.013

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is associated with progressive decline in T cell functions and increased frequency of infections, autoimmune phenomenon, and cancer. Memory T cells rapidly acquire effector functions to kill infected and malignant cells and/or inhibit their replication. Recently, memory T cells have been further classified into central and effector memory T cells (and early and intermediate T cells by some investigators). In aging, memory T cells are accumulated; however, these subpopulations of memory and effector T cells have not been fully characterized and changes in central memory and effector memory T cells in aged humans have not been described. In this article, we have further defined naive, central memory, effector memory, and effector CD8 + T cells in humans and their changes in aged humans. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：545 / 550

页数：6

共 42 条

[1]

Aggarwal S, 1999, J IMMUNOL, V162, P2154

[2] TNF-α-induced apoptosis in neonatal lymphocytes: TNFRp55 expression and downstream pathways of apoptosis [J].

Aggarwal, S ;

Gollapudi, S ;

Yel, L ;

Gupta, AS ;

Gupta, S .

GENES AND IMMUNITY, 2000, 1 (04) :271-279

[3] Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections [J].

Appay, V ;

Dunbar, PR ;

Callan, M ;

Klenerman, P ;

Gillespie, GMA ;

Papagno, L ;

Ogg, GS ;

King, A ;

Lechner, F ;

Spina, CA ;

Little, S ;

Havlir, DV ;

Richman, DD ;

Gruener, N ;

Pape, G ;

Waters, A ;

Easterbrook, P ;

Salio, M ;

Cerundolo, V ;

McMichael, AJ ;

Rowland-Jones, SL .

NATURE MEDICINE, 2002, 8 (04) :379-385

[4] LYMPHOCYTE HOMING AND LEUKOCYTE ROLLING AND MIGRATION ARE IMPAIRED IN L-SELECTIN-DEFICIENT MICE [J].

ARBONES, ML ;

ORD, DC ;

LEY, K ;

RATECH, H ;

MAYNARDCURRY, C ;

OTTEN, G ;

CAPON, DJ ;

TEDDER, TF .

IMMUNITY, 1994, 1 (04) :247-260

[5] Down-regulation of CD28 expression by TNF-α [J].

Bryl, E ;

Vallejo, AN ;

Weyand, CM ;

Goronzy, JJ .

JOURNAL OF IMMUNOLOGY, 2001, 167 (06) :3231-3238

[6] Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo [J].

Callan, MFC ;

Tan, L ;

Annels, N ;

Ogg, GS ;

Wilson, JDK ;

O'Callaghan, CA ;

Steven, N ;

McMichael, AJ ;

Rickinson, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (09) :1395-1402

[7] 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3β receptor CCR7 [J].

Campbell, JJ ;

Bowman, EP ;

Murphy, K ;

Youngman, KR ;

Siani, MA ;

Thompson, DA ;

Wu, LJ ;

Zlotnik, A ;

Butcher, EC .

JOURNAL OF CELL BIOLOGY, 1998, 141 (04) :1053-1059

[8] ICOS co-stimulatory receptor is essential for T-cell activation and function [J].

Dong, C ;

Juedes, AE ;

Temann, UA ;

Shresta, S ;

Allison, JP ;

Ruddle, NH ;

Flavell, RA .

NATURE, 2001, 409 (6816) :97-101

[9] DECLINE IN CD28(+) T-CELLS IN CENTENARIANS AND IN LONG-TERM T-CELL CULTURES - A POSSIBLE CAUSE FOR BOTH IN-VIVO AND IN-VITRO IMMUNOSENESCENCE [J].

EFFROS, RB ;

BOUCHER, N ;

PORTER, V ;

ZHU, XM ;

SPAULDING, C ;

WALFORD, RL ;

KRONENBERG, M ;

COHEN, D ;

SCHACHTER, F .

EXPERIMENTAL GERONTOLOGY, 1994, 29 (06) :601-609

[10] INCREASED CYTOKINE PRODUCTION IN MONONUCLEAR-CELLS OF HEALTHY ELDERLY PEOPLE [J].

FAGIOLO, U ;

COSSARIZZA, A ;

SCALA, E ;

FANALESBELASIO, E ;

ORTOLANI, C ;

COZZI, E ;

MONTI, D ;

FRANCESCHI, C ;

PAGANELLI, R .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (09) :2375-2378

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