Nociceptin orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice

被引:43
作者
Hiramatsu, M [1 ]
Inoue, K [1 ]
机构
[1] Meijo Univ, Fac Pharmaceut Sci, Dept Chem Pharmacol, Nagoya, Aichi 4688503, Japan
关键词
nocistatin; nociceptin; orphanin FQ; kappa-opioid receptor; dynorphin A; spontaneous alternation; passive avoidance; learning and memory; cholinergic neuronal system;
D O I
10.1038/sj.bjp.0702595
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 Nociceptin, also known as orphanin FQ, is an endogenous ligand for the orphan opioid receptor-like receptor 1 (ORL1) and involves in various functions in the central nervous system (CNS). On the other hand, nocistatin is recently isolated from the same precursor as nociceptin and blocks nociceptin-induced allodynia and hyperalgesia. 2 Although ORL1 receptors which display a high degree of sequence homology with classical opioid receptors are abundant in the hippocampus, little is known regarding their role in learning and memory. 3 The present study was designed to investigate whether nociceptin/orphanin FQ and nocistatin could modulate impairment of learning and memory induced by scopolamine, a muscarinic cholinergic receptor antagonist, using spontaneous alternation of Y-maze and step-down type passive avoidance tasks in mice. 4 While nocistatin (0.5-5.0 nmol mouse(-1), i.c.v.) administered 30 min before spontaneous alternation performance or the training session of the passive avoidance task, had no effect on spontaneous alternation or passive avoidance behaviours, a lower per cent alternation and shorter median step-down latency in the retention test were obtained in nociceptin (1.5 and/or 5.0 nmol mouse(-1), i.c.v.)-treated normal mice. 5 Administration of nocistatin (1.5 and/or 5.0 nmol mouse(-1), i.c.v.) 30 min before spontaneous alternation performance or the training session of the passive avoidance task, attenuated the scopolamine-induced impairment of spontaneous alternation and passive avoidance behaviours. 6 These results indicated that nocistatin, a new biologically active peptide, ameliorates impairments of spontaneous alternation and passive avoidance induced by scopolamine, and suggested that these peptides play opposite roles in learning and memory.
引用
收藏
页码:655 / 660
页数:6
相关论文
共 35 条
  • [21] PLACE NAVIGATION IMPAIRED IN RATS WITH HIPPOCAMPAL-LESIONS
    MORRIS, RGM
    GARRUD, P
    RAWLINS, JNP
    OKEEFE, J
    [J]. NATURE, 1982, 297 (5868) : 681 - 683
  • [22] Newhouse P A, 1990, Adv Exp Med Biol, V282, P65
  • [23] Primary structure and tissue distribution of the orphanin FQ precursor
    Nothacker, HP
    Reinscheid, RK
    Mansour, A
    Henningsen, RA
    Ardati, A
    Monsma, FJ
    Watson, SJ
    Civelli, O
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) : 8677 - 8682
  • [24] Nocistatin, a peptide that blocks nociceptin action in pain transmission
    Okuda-Ashitaka, E
    Minami, T
    Tachibana, S
    Yoshihara, Y
    Nishiuchi, Y
    Kimura, T
    Ito, S
    [J]. NATURE, 1998, 392 (6673) : 286 - 289
  • [25] ORPHANIN-FQ - A NEUROPEPTIDE THAT ACTIVATES AN OPIOID-LIKE G-PROTEIN-COUPLED RECEPTOR
    REINSCHEID, RK
    NOTHACKER, HP
    BOURSON, A
    ARDATI, A
    HENNINGSEN, RA
    BUNZOW, JR
    GRANDY, DK
    LANGEN, H
    MONSMA, FJ
    CIVELLI, O
    [J]. SCIENCE, 1995, 270 (5237) : 792 - 794
  • [26] Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats
    Sandin, J
    Georgieva, J
    Schott, PA
    Ogren, SO
    Terenius, L
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (01) : 194 - 197
  • [27] ATTENUATION OF SCOPOLAMINE-INDUCED IMPAIRMENT OF SPONTANEOUS-ALTERNATION BEHAVIOR BY ANTAGONIST BUT NOT INVERSE AGONIST AND AGONIST BETA-CARBOLINES
    SARTER, M
    BODEWITZ, G
    STEPHENS, DN
    [J]. PSYCHOPHARMACOLOGY, 1988, 94 (04) : 491 - 495
  • [28] Identification of opioid receptor-like (ORL1) peptide-stimulated [S-35]GTP gamma S binding in rat brain
    Sim, LJ
    Xiao, RY
    Childers, SR
    [J]. NEUROREPORT, 1996, 7 (03) : 729 - 733
  • [29] Sim LJ, 1997, J COMP NEUROL, V386, P562, DOI 10.1002/(SICI)1096-9861(19971006)386:4<562::AID-CNE4>3.0.CO
  • [30] 2-0