Targeting RAS and PI3K in lung cancer

被引：61

作者：

Downward, Julian ^{[1
]}

机构：

[1] Canc Res UK London Res Inst, London WC2A 3PX, England

来源：

NATURE MEDICINE | 2008年 / 14卷 / 12期

关键词：

D O I：

10.1038/nm1208-1315

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phosphoinositide 3-kinase (PI3K) and RAS oncoproteins are activated in many major tumor types and control linked signaling pathways. An inhibitor of PI3K is now shown to shrink tumors in transgenic mouse cancer models. The drug also blocks RAS-induced lung tumors when combined with an inhibitor of mitogen-activated protein kinase kinase (pages 1351–1356).

引用

页码：1315 / 1316

页数：3

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