Genomes and knowledge - a questionable relationship?

被引：23

作者：

Whitworth, David E. ^{[1
]}

机构：

[1] Aberystwyth Univ, Inst Biol Environm & Rural Sci, Aberystwyth SY23 3DD, Dyfed, Wales

来源：

TRENDS IN MICROBIOLOGY | 2008年 / 16卷 / 11期

关键词：

D O I：

10.1016/j.tim.2008.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The availability of bacterial genome sequences has ushered in an era of post-genomic research - accelerating and often enabling molecular genetic analyses. For bacteriologists focussing on an individual bacterium, comparing genomes has also led to a greater understanding of their favoured organism through contextualization. But how does the value of such contextualization vary with the number of available genomes? It seems that for most genome metrics, comparison against approximately 100 genomes is sufficient, with comparison against further genomes not considerably affecting the contextual knowledge gained. It appears that quality, rather than quantity, might be the most important factor when comparing genomes.

引用

页码：512 / 519

页数：8

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