Nervous system pathology: The fibrin perspective

被引：55

作者：

Akassoglou, K ^{[1
]}

Strickland, S ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Neurobiol & Genet, New York, NY 10021 USA

来源：

BIOLOGICAL CHEMISTRY | 2002年 / 383卷 / 01期

关键词：

coagulation; extracellular matrix; inflammation; multiple sclerosis; sciatic nerve;

D O I：

10.1515/BC.2002.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies of extracellular matrix (ECM) biology in the nervous system have mainly focused on laminin, fibronectin and tenascin-R, proteins that are present during nervous system development and normal function. However, during disease, fibrin, which physiologically is not present in the nervous tissue, is detected at nervous tissue lesions. This review summarizes evidence that correlates fibrin deposition with neuropathology and presents recent findings on cellular mechanisms and intracellular signaling pathways regulated by fibrin that might contribute to nervous system disease.

引用

页码：37 / 45

页数：9

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[91] EXCITOTOXIN-INDUCED NEURONAL DEGENERATION AND SEIZURE ARE MEDIATED BY TISSUE-PLASMINOGEN ACTIVATOR [J].