Analysis of elasticity and deformability of erythrocytes using micro-channel flow system and atomic force microscope

被引：3

作者：

Minamitani, H ^{[1
]}

Tsukada, K ^{[1
]}

Kawamura, T ^{[1
]}

Sekizuka, E ^{[1
]}

Oshio, C ^{[1
]}

机构：

[1] Keio Univ, Dept Biomed Engn, Grad Sch Sci & Technol, Yokohama, Kanagawa 223, Japan

来源：

1ST ANNUAL INTERNATIONAL IEEE-EMBS SPECIAL TOPIC CONFERENCE ON MICROTECHNOLOGIES IN MEDICINE & BIOLOGY, PROCEEDINGS | 2000年

关键词：

D O I：

10.1109/MMB.2000.893743

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Mechanical properties of erythrocytes under diabetic and some other physico-chemical conditions were measured by using transparent micro-channel flow system for the analysis of erythrocyte deformability and also by using atomic force microscope (AFM) for the analysis of microscopic elasticity of the erythrocyte cell membrane respectively. Deformability of diabetic erythrocytes was significantly lower than that of healthy controls, especially at higher shear rate. The spring constant and the Young's modulus of diabetic erythrocytes were much higher than those of healthy controls. These erythrocytes were obviously stiffened to be hard to deform themselves in the capillary flow passage that may follow to the growth of microangiopathy.

引用

页码：68 / 71

页数：4

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