The nonribosomal code

被引:69
作者
von Döhren, H
Dieckmann, R
Pavela-Vrancic, M
机构
[1] TU Biochem OE2, D-10587 Berlin, Germany
[2] BrainTec GmbH, D-14943 Luckenwalde, Germany
[3] Univ Split, Fac Nat Sci Math & Educ, Split 21000, Croatia
来源
CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 10期
关键词
D O I
10.1016/S1074-5521(00)80014-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
How genes are expressed and translated into proteins (using mRNA, codons and tRNAs as adaptor molecules) forms the basis of the 'genetic code'. Many peptides are synthesized nonribosomally, however, by large protein complexes that also serve as templates. Recent advances have shed light on what the nonribosomal code is and how it can be read.
引用
收藏
页码:R273 / R279
页数:7
相关论文
共 42 条
[21]  
KLEINKAUF H, 1982, TRENDS ANTIBIOTIC RE, P220
[22]   How do peptide synthetases generate structural diversity? [J].
Konz, D ;
Marahiel, MA .
CHEMISTRY & BIOLOGY, 1999, 6 (02) :R39-R48
[23]  
LEENDERS F, 1999, THESIS TU BERLIN
[24]   Aminoacylation error correction [J].
Lin, L ;
Hale, SP ;
Schimmel, P .
NATURE, 1996, 384 (6604) :33-34
[25]   Modular peptide synthetases involved in nonribosomal peptide synthesis [J].
Marahiel, MA ;
Stachelhaus, T ;
Mootz, HD .
CHEMICAL REVIEWS, 1997, 97 (07) :2651-2673
[26]  
MENDEL D, 1995, ANNU REV BIOPH BIOM, V24, P435, DOI 10.1146/annurev.bb.24.060195.002251
[27]  
Pauling L :., 1957, Festschrift Prof. Dr. Arthur Stoll, P597
[28]   Editing of non-cognate aminoacyl adenylates by peptide synthetases [J].
Pavela-Vrancic, M ;
Dieckmann, R ;
von Döhren, H ;
Kleinkauf, H .
BIOCHEMICAL JOURNAL, 1999, 342 :715-719
[29]  
Santi D V, 1974, Methods Enzymol, V29, P620
[30]   Targeted alteration of the substrate specificity of peptide synthetases by rational module swapping [J].
Schneider, A ;
Stachelhaus, T ;
Marahiel, MA .
MOLECULAR AND GENERAL GENETICS, 1998, 257 (03) :308-318