Total synthesis of (-)-sporochnol A, the fish deterrent, from a chiral malonate

被引：27

作者：

Fadel, A ^{[1
]}

Vandromme, L ^{[1
]}

机构：

[1] Univ Paris Sud, Inst Chim Mol Orsay, CNRS, Lab Carbocycles, F-91405 Orsay, France

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(99)00086-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

From a single chiron, the homochiral benzylic malonic acid ester (R)-(+)-2 available with high enantiomeric excess by enzymatic hydrolysis (PLE acetonic powder), enantiomerically pure (-)-sporochnol A 1 was prepared. This versatile method allows preparation of sporochnol 1, via aldehydes 7 and 15, in good overall yield. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1153 / 1162

页数：10

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