Antiproliferative effects of the readily extractable fractions prepared from various Citrus juices on several cancer cell lines

被引：31

作者：

Kawaii, S ^{[1
]}

Tomono, Y ^{[1
]}

Katase, E ^{[1
]}

Ogawa, K ^{[1
]}

Yano, M ^{[1
]}

机构：

[1] Natl Inst Fruit Tree Sci, Shizuoka 4240204, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1999年 / 47卷 / 07期

关键词：

citrus; readily extractable fraction; A549; B16; melanoma; 4A5; CCRF-HSB-2; TGBC11TKB; human foreskin keratinocytes; human umbilical vein endothelial cells;

D O I：

10.1021/jf9812228

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

To eliminate the masking effect by flavonoid glycosides, which comprise similar to 70% of conventionally prepared sample, the readily extractable fraction from Citrus juice, which was prepared by adsorbing on HP-20 resin and eluting with ethanol and acetone from the resin, was subjected to antiproliferative tests against several cancer cell lines. Screening of 34 Citrus juices indicated that King (Citrus nobilis) strongly inhibited proliferation of all cancer cell lines examined. Sweet lime and Kabuchi inhibited three of the four cancer cell lines. In contrast, these samples were substantially less cytotoxic toward normal human cell lines.

引用

页码：2509 / 2512

页数：4

共 18 条

[1]

ATTAWAY JA, 1994, FOOD PHYTOCHEMICALS, V1, P240

[2]

BENAVENTEGARCIA O, 1997, J AGR FOOD CHEM, V45, P4506

[3] QUERCETIN AND RUTIN AS INHIBITORS OF AZOXYMETHANOL-INDUCED COLONIC NEOPLASIA [J].