Novel approaches for identifying genes regulating lymphocyte development and function

被引：8

作者：

Loy, AL ^{[1
]}

Goodnow, CC

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, ACRF Genet Lab, Canberra, ACT 2601, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, Canberra, ACT 2601, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(02)00331-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The draft sequence of the human and mouse genomes provides an unparalleled opportunity for understanding the genetic control of immune-cell development. Strategies can begin with a gene sequence and pursue a putative immune-system function by employing mRNA-expression profiling or creating gene knockouts in embryonic stem cells. The latter can be produced by utilising the Cre/Lox system, a tetracycline operon, a gene-trap method or chemical mutagenesis. Alternatively, mutant phenotypes (derived using the mutagen ethylnitrosourea) can be traced back to gene sequences.

引用

页码：260 / 265

页数：6

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