Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule

被引：129

作者：

Maines, JZ ^{[1
]}

Wasserman, SA ^{[1
]}

机构：

[1] Univ Calif San Diego, Ctr Mol Genet, La Jolla, CA 92093 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/11091

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Boule, a Drosophila orthologue of the vertebrate Dazl fertility factors, is a testis-specific regulator of meiotic entry and germline differentiation. Mutations inactivating either Boule, which is an RNA-binding protein, or Twine, which is a Cdc25-type phosphatase, block meiotic entry in males. Here we show that twins and boule interact genetically. We also find that protein expression from twine messenger RNA correlates with cytoplasmic accumulation of Boule and is markedly reduced by boule mutations. Remarkably, heterologous expression of Twine rescues the boule meiotic-entry defect, indicating that the essential function of Boule at the transition from G2 to M phase during meiosis is in the control of Twine translation.

引用

页码：171 / 174

页数：4