Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations

被引：32

作者：

Cherkaoui, S ^{[1
]}

Mateus, L ^{[1
]}

Christen, P ^{[1
]}

Veuthey, JL ^{[1
]}

机构：

[1] Univ Geneva, Lab Pharmaceut Analyt Chem, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1999年 / 21卷 / 01期

关键词：

atropine and scopolamine derivatives; pharmaceuticals; capillary electrophoresis; nonaqueous media;

D O I：

10.1016/S0731-7085(99)00141-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple nonaqueous capillary electrophoresis method is described for the separation of several atropine and scopolamine related drugs. The analysis of these pharmaceutical compounds was performed in a methanol-acetonitrile (25/75, v/v) mixture containing 25 mM ammonium acetate and 1 M acetic acid. The robustness was proved using a full factorial design at two levels. The method was validated and successfully applied for the determination of N-butylscopolamine in different pharmaceutical preparations. Results were compared to those obtained by a capillary electrophoresis method based on aqueous media. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：165 / 174

页数：10

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