Downregulation of G protein-coupled receptors

被引：125

作者：

Tsao, P

von Zastrow, M

机构：

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2000年 / 10卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(00)00096-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated pits followed by sorting to lysosomes, has been examined in detail. Specific protein interactions that control the specificity of G-protein-coupled receptor trafficking in this pathway are beginning to be elucidated.

引用

收藏

页码：365 / 369

页数：5

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