Immunogenicity of embryonic stem cells and their progeny

被引：22

作者：

Drukker, Micha ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA USA

来源：

STEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLS | 2006年 / 420卷

关键词：

D O I：

10.1016/S0076-6879(06)20019-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of pluripotent human embryonic stem cells (hESCs) to differentiate into multiple cell types has led to great excitement about their potential use in the treatment of various degenerative and malignant human diseases. Before such a goal is attainable, however, it must be demonstrated that pure populations of specialized cell types can be isolated and transplanted while simultaneously avoiding possible immune-mediated rejection of these cells. In this chapter, I will discuss the utility of the humanized mouse Trimera model as an in vivo experimental system to study the immunological properties of hESCs and their differentiated derivatives.

引用

页码：391 / 409

页数：19

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