Sildenafil influences lower urinary tract symptoms

被引:183
作者
Sairam, K
Kulinskaya, E
McNicholas, TA
Boustead, GB
Hanbury, DC
机构
[1] Lister Hosp, Stevenage SG1 4AB, Herts, England
[2] Univ Hertfordshire, Fac Hlth & Human Sci, HRDSU, Hatfield AL10 9AB, Herts, England
关键词
erectile dysfunction; sildenafil; nitric oxide; smooth muscle; LUTS; IPSS; IIEF;
D O I
10.1046/j.1464-410X.2002.03040.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective To assess the possible relationship between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in men, and whether treatment of their ED with sildenafil influences their LUTS. Patients and methods In all, 112 men with ED attending the andrology outpatient clinic were offered oral sildenafil and reviewed 1 and 3 months after treatment. They completed the International Index of Erectile Function and the International Prostate Symptom Score (IPSS) questionnaires at baseline and each review. Scores were designated to indicate the visit number and differences between the visits calculated. Results A third of the men had an initial IPSS of >7; there was no relationship between baseline urinary and sexual function scores. After treatment with sildenafil, the urinary scores at 3 months correlated strongly with the sexual function scores. There was a significant inverse relationship between the baseline IPSS and sexual function scores after treatment. The overall trend in the IPSS was towards improvement after treatment with sildenafil. Conclusions In men with ED there is no relationship between sexual function scores and urinary symptom scores before treating ED. Treatment with sildenafil appears to improve urinary symptom scores. A lower IPSS at baseline appears to predict a better response to ED therapy with sildenafil.
引用
收藏
页码:836 / 839
页数:4
相关论文
共 25 条
[21]   NONADRENERGIC, NONCHOLINERGIC RELAXATION AND LEVELS OF CYCLIC-NUCLEOTIDES IN RABBIT LOWER URINARY-TRACT [J].
PERSSON, K ;
ANDERSSON, KE .
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1994, 268 (02) :159-167
[22]   The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction [J].
Rosen, RC ;
Riley, A ;
Wagner, G ;
Osterloh, IH ;
Kirkpatrick, J ;
Mishra, A .
UROLOGY, 1997, 49 (06) :822-830
[23]  
Schou J, 1996, SCAND J UROL NEPHROL, V30, P119
[24]   EFFECTS OF NITRIC-OXIDE ON HUMAN AND CANINE PROSTATES [J].
TAKEDA, M ;
TANG, R ;
ELLEN, SMD ;
BURNETT, AL ;
LEPOR, H .
UROLOGY, 1995, 45 (03) :440-446
[25]   A COMPARISON OF TRANSURETHRAL SURGERY WITH WATCHFUL WAITING FOR MODERATE SYMPTOMS OF BENIGN PROSTATIC HYPERPLASIA [J].
WASSON, JH ;
REDA, DJ ;
BRUSKEWITZ, RC ;
ELINSON, J ;
KELLER, AM ;
HENDERSON, WG .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (02) :75-79