Mechanisms of Action and Medicinal Applications of Abscisic Acid

被引:59
作者
Bassaganya-Riera, J. [1 ]
Skoneczka, J.
Kingston, D. G. J. [2 ]
Krishnan, A.
Misyak, S. A.
Guri, A. J.
Pereira, A.
Carter, A. B.
Minorsky, P. [3 ]
Tumarkin, R. [4 ]
Hontecillas, R.
机构
[1] Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Nutr Immunol & Mol Nutr Grp, Blacksburg, VA 24061 USA
[2] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
[3] Mercy Coll, Dept Nat Sci, New York, NY 10522 USA
[4] Sch Dist Philadelphia, Philadelphia, PA 19130 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
Abscisic acid; type II diabetes; immune modulation; botanicals; PPAR gamma; CYCLIC ADP-RIBOSE; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PROLIFERATOR-ACTIVATED RECEPTORS; TEMPERATURE-SIGNALING CASCADE; STOMATAL GUARD-CELLS; CHELATASE H-SUBUNIT; PPAR-GAMMA; BINDING PROTEIN; K+ CHANNELS; MACROPHAGE INFILTRATION;
D O I
10.2174/092986710790226110
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Since its discovery in the early 1960's, abscisic acid (ABA) has received considerable attention as an important phytohormone, and more recently, as a candidate medicinal in humans. In plants it has been shown to regulate important physiological processes such as response to drought stress, and dormancy. The discovery of ABA synthesis in animal cells has generated interest in the possible parallels between its role in plant and animal systems. The importance of this molecule has prompted the development of several methods for the chemical synthesis of ABA, which differ significantly from the biosynthesis of ABA in plants through the mevalonic acid pathway. ABA recognition in plants has been shown to occur at both the intra-and extracellularly but little is known about the perception of ABA by animal cells. A few ABA molecular targets have been identified in vitro (e. g., calcium signaling, G protein-coupled receptors) in both plant and animal systems. A unique finding in mammalian systems, however, is that the peroxisome proliferator-activated receptor, PPAR, is upregulated by ABA in both in vitro and in vivo studies. Comparison of the human PPAR gene network with Arabidopsis ABA-related genes reveal important orthologs between these groups. Also, ABA can ameliorate the symptoms of type II diabetes, targeting PPAR in a similar manner as the thiazolidinediones class of anti-diabetic drugs. The use of ABA in the treatment of type II diabetes, offers encouragement for further studies concerning the biomedical applications of ABA.
引用
收藏
页码:467 / 478
页数:12
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