The pharmacological effect of polysaccharides from Lentinus edodes on the oxidative status and expression of VCAM-1 mRNA of thoracic aorta endothelial cell in high-fat-diet rats

被引：75

作者：

Chen Xu ^{[1
]}

Zhong HaiYan ^{[2
]}

Zeng JianHong ^{[1
]}

Ge Jing ^{[3
]}

机构：

[1] Guilin Med Coll, Pharmaceut Sch, Guilin 541000, Peoples R China

[2] Cent S Univ Forestry & Technol, Beijing, Peoples R China

[3] Guangxi Univ Tradit Chinese Med, Guilin, Guangxi, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2008年 / 74卷 / 03期

关键词：

TC; TG; SOD; rat; high-fat-diet; polysaccharides from Lentinus edodes;

D O I：

10.1016/j.carbpol.2008.03.018

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The aim of this study was to investigate the pharmacological effect of polysaccharides from Lentinus edodes on serum oxidative status and expression of VCAM-1 mRNA of thoracic aorta endothelial cell in high-fat-diet rats. Forty male rats received two different diets during 40 days: standard chow (SC) and high-fat-diet (HF). The result indicates that the administration of polysaccharides from L. edodes significantly reduced serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-c) and enhanced serum antioxidant enzyme activity and thymus and liver index in high-fat rats. In addition, the administration of polysaccharides from L. edodes significantly decreased the increased expression level of VCAM-1 mRNA in group (V) (P < 0.05). In conclusion, our data suggest that the administration of polysaccharides from L. edodes could decrease the increased oxidation stress induced by high-fat-diet and decrease expression of VCAM-1 mRNA of thoracic aorta endothelial cell in rats. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：445 / 450

页数：6

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